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Mononuclear cells from the cord blood and granulocyte-colony stimulating factor-mobilized peripheral blood: is there a potential for treatment of cerebral palsy?

Title
Mononuclear cells from the cord blood and granulocyte-colony stimulating factor-mobilized peripheral blood: is there a potential for treatment of cerebral palsy?
Author
김용주
Keywords
neurotrophic factors; inflammatory cytokines; cord blood; G-CSF mobilized peripheral blood; mononuclear cell; cerebral palsy; children; neural regeneration
Issue Date
2015-12
Publisher
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
Citation
NEURAL REGENERATION RESEARCH, v. 10, NO 12, Page. 2018-2024
Abstract
To investigate a possible therapeutic mechanism of cell therapy in the field of cerebral palsy using granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (mPBMCs), we compared the expression of inflammatory cytokines and neurotrophic factors in PBMCs and mPBMCs from children with cerebral palsy to those from healthy adult donors and to cord blood mononuclear cells donated from healthy newborns. No significant differences in expression of neurotrophic factors were found between PBMCs and mPBMCs. However, in cerebral palsy children, the expression of interleukin-6 was significantly increased in mPBMCs as compared to PBMCs, and the expression of interleukin-3 was significantly decreased in mPBMCs as compared to PBMCs. In healthy adults, the expression levels of both interleukin-1 beta and interleukin-6 were significantly increased in mPBMCs as compared to PBMCs. The expression of brain-derived neurotrophic factors in mPBMC from cerebral palsy children was significantly higher than that in the cord blood or mPBMCs from healthy adults. The expression of G-CSF in mPBMCs from cerebral palsy children was comparable to that in the cord blood but significantly higher than that in mPBMCs from healthy adults. Lower expression of pro-inflammatory cytokines (interleukin-1 beta, interleukin-3, and -6) and higher expression of anti-inflammatory cytokines (interleukin-8 and interleukin-9) were observed from the cord blood and mPBMCs from cerebral palsy children rather than from healthy adults. These findings indicate that mPBMCs from cerebral palsy and cord blood mononuclear cells from healthy newborns have the potential to become seed cells for treatment of cerebral palsy.
URI
http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=12;spage=2018;epage=2024;aulast=Kohhttp://hdl.handle.net/20.500.11754/30147
ISSN
1673-5374; 1876-7958
DOI
10.4103/1673-5374.172321
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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