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HiXCorr: a portable high-speed X-Corr engine for high-resolution tandem mass spectrometry

Title
HiXCorr: a portable high-speed X-Corr engine for high-resolution tandem mass spectrometry
Author
박희진
Keywords
DATABASE
Issue Date
2015-12
Publisher
OXFORD UNIV PRESS
Citation
BIOINFORMATICS, v. 31, NO 24, Page. 4026-4028
Abstract
Peptide identification is an important problem in proteomics. One of the most popular scoring schemes for peptide identification is X-Corr (cross-correlation). Since calculating X-Corr is computationally intensive, a lot of efforts have been made to develop fast X-Corr engines. However, the existing X-Corr engines are not suitable for high-resolution MS/MS spectrometry because they are either slow or require a specific type of CPU. We present a portable high-speed X-Corr engine for high-resolution tandem mass spectrometry by developing a novel algorithm for calculating X-Corr. The algorithm enables X-Corr calculation 1.25-49 times faster than previous algorithms for 0.01 Da fragment tolerance. Furthermore, our engine is easily portable to any machine with different types of CPU because it is developed in C language. Hence, our X-Corr engine will expedite peptide identification by high-resolution tandem mass spectrometry.
URI
https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btv490http://hdl.handle.net/20.500.11754/29562
ISSN
1367-4803; 1460-2059
DOI
10.1093/bioinformatics/btv490
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > COMPUTER SCIENCE AND ENGINEERING(컴퓨터공학부) > Articles
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