Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하태경 | - |
dc.date.accessioned | 2017-09-14T02:45:12Z | - |
dc.date.available | 2017-09-14T02:45:12Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | OBESITY SURGERY, v. 25, NO 11, Page. 2002-2010 | en_US |
dc.identifier.issn | 0960-8923 | - |
dc.identifier.issn | 1708-0428 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs11695-015-1636-4 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29141 | - |
dc.description.abstract | We evaluated metabolic changes after vertical sleeve gastrectomy (VSG) surgery in a rat model using proteomics and metabolomic profiling in liver and serum. Rats were randomly divided into two groups: sham (n = 10) and VSG (n = 12). Food intake, body weight, blood glucose, insulin, and thyroid hormone levels were measured. Two-dimensional electrophoresis, nuclear resonance spectroscopy, mass spectroscopy, immunofluorescence, and immunoblot analyses were used to determine and validate changes in metabolites and proteins in liver tissue and serum samples. Food intake and body weight decreased after VSG group (p < 0.05 and p < 0.05, respectively). Random blood glucose (sham, 183.3 +/- 5.6 mg/dL; VSG, 138.5 +/- 3.7 mg/dL) decreased while random insulin (sham, 0.45 +/- 0.16 mu g/L; VSG, 1.05 +/- 0.18 mu g/L) increased after VSG (p < 0.05 and p < 0.01, respectively). We found that expressions of gluconeogenic enzymes (phosphoenolpyruvate carboxykinase-1 and glucose-6-phosphatase) and concentrations of pyruvate and malate decreased while lactate, NADH, NADPH, glucose, and AMP/ATP ratio increased after VSG. Thyroid hormones, triiodothyronine (T3) and free thyroxine (fT4), decreased after VSG. This study proves that VSG suppresses hepatic glucose production. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (No. 2014R1A5A2010008), the research fund of Hanyang University (HY-2012-MC), and the Keimyung University Medical School Research Promoting Grant launched from 2012. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Vertical sleeve gastrectomy | en_US |
dc.subject | Proteome | en_US |
dc.subject | Metabolome | en_US |
dc.subject | Gluconeogenesis | en_US |
dc.title | Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 25 | - |
dc.identifier.doi | 10.1007/s11695-015-1636-4 | - |
dc.relation.page | 2002-2010 | - |
dc.relation.journal | OBESITY SURGERY | - |
dc.contributor.googleauthor | Lho, Yunmee | - |
dc.contributor.googleauthor | le Roux, Carel W. | - |
dc.contributor.googleauthor | Park, Hyeon Soo | - |
dc.contributor.googleauthor | Kim, Gon Sup | - |
dc.contributor.googleauthor | Jung, Jeeyoun | - |
dc.contributor.googleauthor | Hwang, Geum-Sook | - |
dc.contributor.googleauthor | Seo, Youn Kyoung | - |
dc.contributor.googleauthor | Ha, Tae Kyung | - |
dc.contributor.googleauthor | Ha, Eunyoung | - |
dc.relation.code | 2015000679 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | missurgeon | - |
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