All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci

Title
All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci
Authors
KUTZNER, ARNE HOLGER
Keywords
FAM72; neuron; cancer; homo; p17
Issue Date
2015-11
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
GENOMICS, v. 106, NO 5, Page. 278-285
Abstract
FAM72 is a novel neuronal progenitor cell (NPC) self-renewal supporting protein expressed under physiological conditions at low levels in other tissues. Accumulating data indicate the potential pivotal tumourigenic effects of FAM72. Our in silico human genome-wide analysis (GWA) revealed that the FAM72 gene family consists of four human-specific paralogous members, all of which are located on chromosome (chr) 1. Unique asymmetric FAM72 segmental gene duplications are most likely to have occurred in conjunction with the paired genomic neighbour SRGAP2 (SLIT-ROBO Rho GTPase activating protein), as both genes have four paralogues in humans but only one vertebra-emerging orthologue in all other species. No species with two or three FAM72/SRGAP2 gene pairs could be identified, and the four exclusively human-defining ohnologues, with different mutation patterns in Homo neanderthalensis and Denisova hominin, may remain under epigenetic control through long non-coding (lnc) RNAs. (C) 2015 Published by Elsevier Inc.
URI
http://www.sciencedirect.com/science/article/pii/S0888754315300185http://hdl.handle.net/20.500.11754/29115
ISSN
0888-7543; 1089-8646
DOI
http://dx.doi.org/10.1016/j.ygeno.2015.07.003
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COLLEGE OF ENGINEERING[S](공과대학) > ETC
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