Correlation between F-18-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer
- Correlation between F-18-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer
- Triple-negative breast cancer; F-18-FDGPET/CT; Immunohistochemistry; Ki-67 proliferation index; Cancer metabolism
- Issue Date
- EUROPEAN RADIOLOGY, v. 25, NO 11, Page. 3314-3321
- The purpose of this study was to investigate whether a correlation exists between F-18-fluorodeoxyglucose (FDG) uptake and prognostic factors in triple-negative breast cancer (TNBC).
Between January 2009 and December 2013, 103 patients (mean age, 50.6 years) with primary TNBC (mean, 2.6 cm; range, 1.0-6.5 cm) underwent F-18-FDG PET/CT for initial staging. Correlations between maximum standardized uptake value (SUVmax) on PET/CT and prognostic factors including tumour size, nodal status, histological grade, Ki-67 proliferation index, tumour suppressor p53, and 'basal-like' markers (epidermal growth factor receptor and CK 5/6) were assessed.
The mean SUVmax of the 103 tumours was 10.94 +/- 5.25 (range: 2-32.8). There was a positive correlation between SUVmax and Ki-67 (Spearman's rho = 0.29, P = 0.003) and tumour size (Spearman's rho = 0.27, P = 0.006), whereas this relationship was not observed in the nodal status, histological grade, p53 status and 'basal-like' phenotypes. In a multivariate regression analysis, Ki-67 (P < 0.001) and tumour size (P = 0.009) were significantly associated with SUVmax in TNBCs.
Increased F-18-FDG uptake on PET/CT was correlated with a high Ki-67 proliferation index and larger tumour size in TNBC. These results suggest a potential role of F-18-FDG PET/CT in identifying TNBC with more aggressive behaviour.
aEuro cent A wide range of FDG uptake reflected heterogeneity of cancer metabolism.
aEuro cent FDG uptake was correlated with the Ki-67 proliferation index in TNBC.
aEuro cent FDG uptake was correlated with tumour size in TNBC.
aEuro cent FDG uptake was not correlated with 'basal-like' phenotype.
- 0938-7994; 1432-1084
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