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N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates

Title
N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates
Author
신승훈
Keywords
copper; N-arylation; indoles; copper-mediated synthesis; heterocyclic amines; metal-catalyzed
Issue Date
2015-11
Publisher
GEORG THIEME VERLAG KG
Citation
SYNTHESIS, v. 47, NO 21, Page. 3301-3308
Abstract
Indole-carboxylates are N-arylated with 2-bromopyridines using stoichiometric copper(II) oxide/potassium carbonate to give various N-(2-pyridyl)-substituted indole-2-carboxylates and with bromobenzenes using stoichiometric copper(I) iodide/N,N'-dimethylethylenediamine to give various N-#substituted phenyl#-substituted indole-2-carboxylates. These results expand the scope of metal-catalyzed N-arylation using heterocyclic amines with steric bulk and weak nucleophilicity.
URI
https://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1560065http://hdl.handle.net/20.500.11754/29098
ISSN
0039-7881; 1437-210X
DOI
10.1055/s-0035-1560065
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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