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Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs

Title
Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs
Author
김진웅
Keywords
Transdermal delivery; Photothermal effect; Phase changing materials; Au nanoparticles; Block copolymer micelle
Issue Date
2015-11
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 135, Page. 324-331
Abstract
We describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(epsilon-caprolactone) (PCL) biodegradable core and a hyperbranched polyglycol (hbPG) shell. The hbPG block formed micelles at a low-molecular-weight fraction of a low-molecular-weight block copolymer. The composite micelles showed excellent biocompatibility with cell viability at high concentrations. Visible light irradiation (lambda = 520 nm) of the composite micelles induced the photothermal effects of the AuNPs and melting of the PCM (lauric acid); hence, the drugs were released along with the PCM liquid. The release rate was controlled by the light intensity. Based on in vitro and in vivo skin penetration studies, the skin permeability of the drug remarkably improved under mild light irradiation (18 J/cm(2)) that was much lower than the dose that causes skin damage. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0927776515300953?via%3Dihubhttp://hdl.handle.net/20.500.11754/29069
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2015.07.061
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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