Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철근 | - |
dc.date.accessioned | 2017-09-11T05:14:29Z | - |
dc.date.available | 2017-09-11T05:14:29Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | GENES & GENOMICS, v. 37, NO 12, Page. 1073-1079 | en_US |
dc.identifier.issn | 1976-9571 | - |
dc.identifier.issn | 2092-9293 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs13258-015-0364-4 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29031 | - |
dc.description.abstract | In the present study, necrosis inhibitor-5 (NecroX-5), a novel Cyclopentylamino carboxymethylthiazolylindole (NecroX) series compound was investigated for its protective role against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in a zebrafish model of Parkinson's disease (PD). MPTP-induced locomotor behavior was measured in zebrafish larvae and the protein expression level of tyrosine hydroxylase (TH) was estimated in zebrafish larva homogenates. MPTP (15 mu M) induced a significant (p ˂ 0.05) impairment in zebrafish larvae locomotor behavior. Treatment with NecroX-5 at various doses (3.75, 7.5 and 15 mu M) significantly and dose dependently (p ˂ 0.05) restored MPTP-induced locomotor impairments in zebrafish larvae. Further, NecroX-5 significantly attenuated the MPTP-induced decrease in zebrafish TH protein expression levels. The effects observed by NecroX-5 were almost two fold higher when compared with the antioxidant, minocycline. In conclusion, the neuroprotective activity exhibited by NecroX-5 by attenuating MPTP-induced locomotor impairments and dopaminergic TH expression in zebrafish warrants further development of NecroX-5 as a novel neuroprotectant in the treatment of neurodegenerative disorders including PD. | en_US |
dc.description.sponsorship | The National Research Foundation of Korea (NRF-2010-0012391) supported this work. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | NecroX | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Tyrosine hydroxylase | en_US |
dc.subject | Zebrafish | en_US |
dc.subject | Parkinson's disease | en_US |
dc.title | Necrosis inhibitor-5 (NecroX-5), attenuates MPTP-induced motor deficits in a zebrafish model of Parkinson's disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1007/s13258-015-0364-4 | - |
dc.relation.page | 1073-1079 | - |
dc.relation.journal | GENES & GENOMICS | - |
dc.contributor.googleauthor | Liu, Jun-Cheng | - |
dc.contributor.googleauthor | Koppula, Sushruta | - |
dc.contributor.googleauthor | Huh, Se-Jong | - |
dc.contributor.googleauthor | Park, Pyo-Jam | - |
dc.contributor.googleauthor | Kim, Chul-Geun | - |
dc.contributor.googleauthor | Lee, Chang-Joong | - |
dc.contributor.googleauthor | Kim, Chan-Gil | - |
dc.relation.code | 2015010102 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | cgkim | - |
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