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DC FieldValueLanguage
dc.contributor.author고성호-
dc.date.accessioned2017-08-10T02:43:42Z-
dc.date.available2017-08-10T02:43:42Z-
dc.date.issued2015-10-
dc.identifier.citationJOURNAL OF CLINICAL NEUROLOGY, v. 11, NO 4, Page. 297-304en_US
dc.identifier.issn1738-6586-
dc.identifier.issn2005-5013-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.3988/jcn.2015.11.4.297-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/28440-
dc.description.abstractNeurologic deficits resulting from stroke remain largely intractable, which has prompted thousands of studies aimed at developing methods for treating these neurologic sequelae. Endogenous neurogenesis is also known to occur after brain damage, including that due to cerebral infarction. Focusing on this process may provide a solution for treating neurologic deficits caused by cerebral infarction. The phosphatidylinositol-3-kinase (PI3K) pathway is known to play important roles in cell survival, and many studies have focused on use of the PI3K pathway to treat brain injury after stroke. Furthermore, since the PI3K pathway may also play key roles in the physiology of neural stem cells (NSCs), eliciting the appropriate activation of the PI3K pathway in NSCs may help to improve the sequelae of cerebral infarction. This review describes the PI3K pathway, its roles in the brain and NSCs after cerebral infarction, and the therapeutic possibility of activating the pathway to improve neurologic deficits after cerebral infarction.en_US
dc.description.sponsorshipThis work was supported by a grant from the Korea Research Foundation (no. 2012R1A1B3000473), and a grant from the NanoBio R&D Program of the Korea Science and Engineering Foundation, funded by the Ministry of Education, Science and Technology (no. 2007-04717).en_US
dc.language.isoenen_US
dc.publisherKOREAN NEUROLOGICAL ASSOCen_US
dc.subjectneural stem cellsen_US
dc.subjectstrokeen_US
dc.subjectphosphatidylinositol-3-kinasesen_US
dc.subjectregenerationen_US
dc.titleThe Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarctionen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume11-
dc.identifier.doi10.3988/jcn.2015.11.4.297-
dc.relation.page297-304-
dc.relation.journalJOURNAL OF CLINICAL NEUROLOGY-
dc.contributor.googleauthorKoh, Seong-Ho-
dc.contributor.googleauthorLo, Eng H.-
dc.relation.code2015012721-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidksh213-


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