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Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's Disease

Title
Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's Disease
Author
Klaus Heese
Keywords
AMYLOID-BETA-PROTEIN; INTRINSICALLY DISORDERED PROTEINS; ACANTHOPANAX-SENTICOSUS HARMS; UBIQUITIN-PROTEASOME SYSTEM; TRANSIENT CEREBRAL-ISCHEMIA; RADICAL OXIDATIVE STRESS; BILOBA EXTRACT EGB-761; MUTANT ALPHA-SYNUCLEIN; TERMINAL HYDROLASE L1; GINKGO-BILOBA
Issue Date
2015-10
Publisher
HINDAWI PUBLISHING CORPORATION
Citation
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Page. 1-17
Abstract
In recent years, there has been an increasing worldwide interest in traditional Chinese medicine (TCM). This increasing demand for TCM needs to be accompanied by a deeper understanding of the mechanisms of action of TCM-based therapy. However, TCM is often described as a concept of Chinese philosophy, which is incomprehensible for Western medical society, thereby creating a gap between TCM and Western medicine (WM). In order to meet this challenge, TCM research has applied proteomics technologies for exploring the mechanisms of action of TCM treatment. Proteomics enables TCM researchers to oversee various pathways that are affected by treatment, as well as the dynamics of their interactions with one another. This review discusses the utility of comparative proteomics to better understand how TCM treatment may be used as a complementary therapy for Alzheimer's disease (AD). Additionally, we review the data from comparative AD-related TCM proteomics studies and establish the relevance of the data with available AD hypotheses, most notably regarding the ubiquitin proteasome system (UPS).
URI
https://www.hindawi.com/journals/ecam/2015/393510/http://hdl.handle.net/20.500.11754/28144
ISSN
1741-427X; 1741-4288
DOI
10.1155/2015/393510
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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