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Significance of the Extracapsular Spread of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma

Title
Significance of the Extracapsular Spread of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma
Author
지용배
Keywords
Thyroid Cancer, Papillary; Metastatic Lymph Node; Extracapsular Spread
Issue Date
2015-09
Publisher
KOREAN SOC OTORHINOLARYNGOL
Citation
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, v. 8, NO 3, Page. 289-294
Abstract
Objectives. The extracapsular spread (ECS) of metastatic lymph nodes is associated with aggressive tumor behavior, and is regarded as a major risk factor for local recurrence in patients with head and neck squamous cell carcinoma. However, the significance of ECS of metastatic lymph nodes has not been well established in well-differentiated thyroid carcinoma. The purpose of this study was to examine this question. Methods. A retrospective review was performed of 335 patients with papillary thyroid carcinoma who underwent total thyroidectomy with lymph node dissection from April 2001 to December 2009. We analyzed various clinical characteristics, pathologic factors, and the size, number, and ECS of foci in metastatic lymph nodes. Results. On pathologic review, 201 of the patients (56.6%) had lymph node metastasis. This was significantly related to age and tumor size. ECS was noted in 64 of these 201 patients (31.8%), and was significantly related to male gender, tumor size, presence of extrathyroidal extension, metastatic lymph node size, and focus size. Recurrence occurred in 13 patients (3.9%), and the presence of ECS was significantly related to recurrence. Conclusion. ECS of metastatic lymph nodes is an important prognostic factor for loco-regional recurrence in papillary thyroid carcinoma.
URI
https://www.e-ceo.org/journal/view.php?doi=10.3342/ceo.2015.8.3.289http://hdl.handle.net/20.500.11754/27777
ISSN
1976-8710; 2005-0720
DOI
10.3342/ceo.2015.8.3.289
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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