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Lung function decline rates according to GOLD goup in patients with chronic obstructive pulmonary disease

Title
Lung function decline rates according to GOLD goup in patients with chronic obstructive pulmonary disease
Author
김태형
Keywords
annual lung function decline; chronic obstructive pulmonary disease; GOLD 2014
Issue Date
2015-09
Publisher
Dove Medical Press
Citation
International Journal of Chronic Obstructive Pulmonary Disease, v. 10, Page. 1819-1827
Abstract
Background Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups A–D were introduced, the lung function changes according to group have been evaluated rarely. Objective We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines. Methods Patients with COPD included in the Korean Obstructive Lung Disease (KOLD) prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1), which was analyzed by random-slope and random-intercept mixed linear regression. Results A total 175 participants were included. No significant postbronchodilator FEV1 decline was observed between the groups (−34.4±7.9 [group A]; −26.2±9.4 [group B]; −22.7±16.0 [group C]; and −24.0±8.7 mL/year [group D]) (P=0.79). The group with less symptoms (−32.3±7.2 vs −25.0±6.5 mL/year) (P=0.44) and the low risk group (−31.0±6.1 vs −23.6±7.7 mL/year) (P=0.44) at baseline showed a more rapid decline in the postbronchodilator FEV1, but the trends were not statistically significant. However, GOLD stages classified by FEV1 were significantly related to the annual lung function decline. Conclusion There was no significant difference in lung function decline rates according to the GOLD groups. Prior classification using postbronchodilator FEV1 predicts decline in lung function better than does the new classification.
URI
https://www.dovepress.com/lung-function-decline-rates-according-to-gold-group-in-patients-with-c-peer-reviewed-article-COPDhttp://hdl.handle.net/20.500.11754/27580
ISSN
1178-2005
DOI
10.2147/COPD.S87766
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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