Treatment outcomes and prognostic factors of nasopharyngeal carcinoma

Title
Treatment outcomes and prognostic factors of nasopharyngeal carcinoma
Authors
박철원
Keywords
Chemotherapy; Concurrent chemoradiation; Nasopharyngeal carcinoma; Prognosis; Radiation therapy
Issue Date
2015-09
Publisher
대한이비인후과학회
Citation
대한이비인후과학회지 두경부외과학, v. 59, NO 3, Page. 222-228
Abstract
Background and ObjectivesZZNasopharyngeal carcinoma is an uncommon disease that is usually found in the advanced stage becuase its anatomical location makes early detection difficult. Radiation therapy or concurrent chemoradiation therapy is mainstay for treatment of nasopharyngeal carcinoma. We evaluated clinical characteristics and treatment outcomes of nasopharyngeal carcinoma and assessed prognostic factors related to survival. Subjects and MethodZZWe retrospectively reviewed medical records of 87 patients who were treated for nasopharyngeal carcinoma from 1994 to 2013. Clinical characteristics, pathologic type, stage, treatment modality, recurrence and survival were investigated. ResultsZZThe mean follow-up period was 66.7 (12-232) months. Recurrence rates were not significantly different between the radiation therapy group and combined chemoradiation groups in the early stage (27.3% vs. 21.6%, p=0.644) and the advanced stage (21.4% vs. 31.3%, p=0.496). Five-year overall survival and disease free survival rate was 74.0% and 58.9%, respectively. Five-year overall survival rate of the combined chemoradiation therapy group was significantly lower than that of the radiation therapy group (64.4% vs. 94.1%, p=0.001). Distant metastasis was significantly correlated with survival in multivariate analysis. ConclusionZZIn this study, the five-year overall survival rate was better in the radiation therapy group than in the combined chemoradiation group. This might be related to the fact that advanced stage disease was more common in the combined chemoradiation group. Further studies with larger study samples and longer follow-up are necessary to verify these results and determine optimal modalities for the treatment of nasopharyngeal carcinoma.
URI
http://www.kjorl.org/journal/view.php?doi=10.3342/kjorl-hns.2016.59.3.222http://hdl.handle.net/20.500.11754/27544
ISSN
2092-6529; 2092-5859
DOI
http://dx.doi.org/10.3342/kjorl-hns.2016.59.3.222
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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