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Chlorhexidine-loaded xanthan gum-based biopolymers for targeted, sustained release of antiseptic agent

Title
Chlorhexidine-loaded xanthan gum-based biopolymers for targeted, sustained release of antiseptic agent
Author
최종훈
Keywords
Chlorhexidine; Xanthan gum biopolymer; Sustained delivery; Antiseptic reagent
Issue Date
2015-09
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 32, Page. 44-48
Abstract
We engineered a chlorhexidine-loaded xanthan gum-based biopolymer for the targeted release of antiseptic agent. To increase the viscosity and adherent properties of the xanthan gum scaffold, biocompatible materials were prepared and added to the scaffold. The chlorhexidine-loaded xanthan gum was gelated prior to physicochemical characterization, and exhibited shear-thinning behavior. Rheological studies were performed to measure biopolymer viscosity using a Brookfield viscometor. As xanthan gum concentration increased, biopolymer viscosity increased as well. Addition of various biocompatible materials resulted in higher or similar viscosities as compared to the chlorhexidine-loaded xanthan gum-based chlorhexidine biopolymer. In this study, we prepared biocompatible, antiseptic, xanthan gum-based biopolymers for the targeted delivery of chlorhexidine. Similar biomaterials may have potential as effective local treatment modalities for temporary disinfection purpose in medical applications. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1226086X15004335http://hdl.handle.net/20.500.11754/27429
ISSN
1226-086X; 1876-794X
DOI
10.1016/j.jiec.2015.09.024
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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