Defining vitamin D deficiency and its relationship to hypertension in postmenopausal Korean women

Title
Defining vitamin D deficiency and its relationship to hypertension in postmenopausal Korean women
Author
신진호
Keywords
NUTRITION EXAMINATION SURVEY; PARATHYROID-HORMONE LEVELS; GENOME-WIDE ASSOCIATION; BODY-FAT DISTRIBUTION; BLOOD-PRESSURE; NATIONAL-HEALTH; D SUPPLEMENTATION; SERUM 25-HYDROXYVITAMIN-D; 1,25-DIHYDROXYVITAMIN D-3; HYPOVITAMINOSIS D
Issue Date
2015-09
Publisher
Mary Ann Liebert
Citation
Journal of Women's Health, v. 24, no.12, page. 1021-1029
Abstract
Background: Inconsistent results regarding the association between low vitamin D level and hypertension (HTN) have led to uncertainty in clinical practice as to the use of vitamin D cutoff value. The aims of this study were to investigate the association between vitamin D deficiency and HTN in postmenopausal women and to determine the clinically significant cutoff value for vitamin D deficiency. Methods: We analyzed data from the Korean National Health and Nutrition Examination Survey 5 database (4107 postmenopausal women, aged 50-79 years). The cutoff value for vitamin D deficiency was based on the changes in parathyroid hormone (PTH) level according to serum 25(OH)D value. Results: PTH levels were significantly higher in groups with serum 25(OH)D <15ng/mL (p<0.001). When a serum 25(OH)D value of 15ng/mL was used as a cutoff value, 35.2% of the subjects were found to be vitamin D deficient. Although the association between 25(OH)D level <15ng/mL and systolic blood pressure did not remain significant after adjusting for season (p=0.30), multiple logistic regression analysis revealed that 25(OH)D level <15ng/mL was an independent risk factor for HTN (adjusted odds ratio [OR] 1.285, 95% confidence interval [CI] 1.024-1.614, p=0.031). Conclusions: Using serum PTH level, we defined vitamin D deficiency as 25(OH)D <15ng/mL in postmenopausal women. Vitamin D deficiency [25(OH)D <15ng/mL] was a significant risk factor for HTN in postmenopausal women.
URI
http://online.liebertpub.com/doi/abs/10.1089/jwh.2015.5358http://hdl.handle.net/20.500.11754/27426
ISSN
1540-9996; 1931-843X
DOI
10.1089/jwh.2015.5358
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE