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Characteristics and significance of minimal and maximal extrathyroidal extension in papillary thyroid carcinoma

Title
Characteristics and significance of minimal and maximal extrathyroidal extension in papillary thyroid carcinoma
Author
지용배
Keywords
Extrathyroidal extension; Papillary thyroid carcinoma; Capsular invasion; Prognosis; Recurrence; Strap muscle invasion
Issue Date
2015-08
Publisher
ELSEVIER SCIENCE BV
Citation
ORAL ONCOLOGY, v. 51, NO 8, Page. 759-763
Abstract
Objectives: Maximal extrathyroidal extension (ETE) is known to be an important prognostic factor in papillary thyroid carcinoma (PTC). However, the significance of minimal ETE is controversial. The aim of this study was to investigate the clinicopathologic characteristics and prognostic significance of minimal vs maximal ETE in PTC. Materials and methods: A group of 967 patients who underwent thyroidectomy for PTC in a tertiary hospital between January 2000 and December 2011 were studied retrospectively. Patients were classified into three groups: absence of ETE, and minimal and maximal ETE. The minimal ETE group was further categorized into two subgroups according to invasion of strap muscles or no invasion (STI+ and STI-). Results: Gender did not differ between the three groups of patients. The mean age of the patients with maximal ETE was significantly higher than in those belonging to the other groups. Tumor size, bilaterality, lymph node metastasis and stage increased significantly according to the degree of ETE. Recurrence and survival rates did not differ between the absence and minimal ETE groups, or between the STI- and STI+ subgroups of minimal ETE. However, the maximal ETE group had significantly higher recurrence and lower survival rates than the other groups (P ˂ 0.001). Conclusion: Maximal ETE is a significant factor for poor prognosis. However, minimal ETE is not associated with increased recurrence or decreased survival in patients with PTC. (C) 2015 Elsevier Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1368837515002328
ISSN
1368-8375; 1879-0593
DOI
10.1016/j.oraloncology.2015.05.010
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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