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DC FieldValueLanguage
dc.contributor.author임미선-
dc.date.accessioned2017-04-25T01:03:15Z-
dc.date.available2017-04-25T01:03:15Z-
dc.date.issued2015-08-
dc.identifier.citationInternational Journal of Stem Cells, v. 8, NO 2, Page. 228-234en_US
dc.identifier.issn2005-3606-
dc.identifier.issn2005-5447-
dc.identifier.urihttp://www.ijstemcell.com/journal/view.html?uid=163&sort=&scale=&key=year&keyword=&s_v=8&s_n=2&pn=vol&year=2015&vmd=Full-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26923-
dc.description.abstractInduced neural precursor cells (iNPCs) are one source of transplantable dopaminergic neurons used in cell therapy for Parkinson’s disease. In the present study, we demonstrate that iNPCs can be generated by transducing Brn2, Ascl1, Myt1L and Bcl-xL in a culture supplemented with several mitogens and subsequently can be differentiated to dopaminergic neurons (DA). However, studies have shown that iDA and/or iNPC-derived DA neurons using various conversion protocols have low efficiency. Here, we show that early exposure of FGF8 to fibroblasts efficiently improves differentiation of DA neurons. So our study demonstrates that FGF8 is a critical factor for generation of iNPC-derived DA neurons.en_US
dc.description.sponsorshipThis work was supported by the Medical Research Center (2008-0062190), the Basic Science Research Program(2011-0008952) through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT, & Future Planning and Hanyang University (201400000000578).en_US
dc.language.isoenen_US
dc.publisherKorean Society for Stem Cell Researchen_US
dc.subjectDirect conversionen_US
dc.subjectFGF8en_US
dc.subjectDopamine neuronen_US
dc.subjectiNPCen_US
dc.titleFGF8 is Essential for Functionality of Induced Neural Precursor Cell-derived Dopaminergic Neuronsen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume8-
dc.identifier.doi10.15283/ijsc.2015.8.2.228-
dc.relation.page228-234-
dc.relation.journalInternational Journal of Stem Cells-
dc.contributor.googleauthorLim, Mi-Sun-
dc.contributor.googleauthorLee, Soo Young-
dc.contributor.googleauthorPark, Chang-Hwan-
dc.relation.code2015027340-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentHBRI-
dc.identifier.pidmam3128-


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