Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임미선 | - |
dc.date.accessioned | 2017-04-25T01:03:15Z | - |
dc.date.available | 2017-04-25T01:03:15Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | International Journal of Stem Cells, v. 8, NO 2, Page. 228-234 | en_US |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.issn | 2005-5447 | - |
dc.identifier.uri | http://www.ijstemcell.com/journal/view.html?uid=163&sort=&scale=&key=year&keyword=&s_v=8&s_n=2&pn=vol&year=2015&vmd=Full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26923 | - |
dc.description.abstract | Induced neural precursor cells (iNPCs) are one source of transplantable dopaminergic neurons used in cell therapy for Parkinson’s disease. In the present study, we demonstrate that iNPCs can be generated by transducing Brn2, Ascl1, Myt1L and Bcl-xL in a culture supplemented with several mitogens and subsequently can be differentiated to dopaminergic neurons (DA). However, studies have shown that iDA and/or iNPC-derived DA neurons using various conversion protocols have low efficiency. Here, we show that early exposure of FGF8 to fibroblasts efficiently improves differentiation of DA neurons. So our study demonstrates that FGF8 is a critical factor for generation of iNPC-derived DA neurons. | en_US |
dc.description.sponsorship | This work was supported by the Medical Research Center (2008-0062190), the Basic Science Research Program(2011-0008952) through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT, & Future Planning and Hanyang University (201400000000578). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Society for Stem Cell Research | en_US |
dc.subject | Direct conversion | en_US |
dc.subject | FGF8 | en_US |
dc.subject | Dopamine neuron | en_US |
dc.subject | iNPC | en_US |
dc.title | FGF8 is Essential for Functionality of Induced Neural Precursor Cell-derived Dopaminergic Neurons | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.15283/ijsc.2015.8.2.228 | - |
dc.relation.page | 228-234 | - |
dc.relation.journal | International Journal of Stem Cells | - |
dc.contributor.googleauthor | Lim, Mi-Sun | - |
dc.contributor.googleauthor | Lee, Soo Young | - |
dc.contributor.googleauthor | Park, Chang-Hwan | - |
dc.relation.code | 2015027340 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | HBRI | - |
dc.identifier.pid | mam3128 | - |
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