Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신정훈 | - |
dc.date.accessioned | 2017-04-19T07:28:12Z | - |
dc.date.available | 2017-04-19T07:28:12Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 13, no. 3, page. 297-303 | en_US |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.issn | 2212-5469 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s13770-016-9054-9 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26834 | - |
dc.description.abstract | A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2014). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | en_US |
dc.subject | Granulocyte-colony stimulating factor | en_US |
dc.subject | Wound healing | en_US |
dc.subject | Local injection | en_US |
dc.title | Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s13770-016-9054-9 | - |
dc.relation.journal | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.contributor.googleauthor | Shen, Guang-Yin | - |
dc.contributor.googleauthor | Park, In-Hwa | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | Joo, Hyun-Woo | - |
dc.contributor.googleauthor | Lee, Yonggu | - |
dc.contributor.googleauthor | Shin, Jeong-Hun | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.contributor.googleauthor | Kim, Hyuck | - |
dc.relation.code | 2015009287 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyapex | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.