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Fascin expression predicts aggressive clinical course in patients with advanced breast cancer

Title
Fascin expression predicts aggressive clinical course in patients with advanced breast cancer
Author
민경환
Keywords
fascin-1 protein; prognosis; invasive ductal carcinoma; human breast cancer
Issue Date
2015-07
Publisher
SPANDIDOS PUBL LTD
Citation
ONCOLOGY LETTERS, v. 10, no. 1, page. 121-130
Abstract
Fascin is an actin cross-linking protein, which regulates actin dynamics and filopodia or spike formation, as well as the epithelial-mesenchymal transition, and has been implicated in cell motility. Although, fascin is pivotal in mediating the aggressive behaviour of various types of cancer, its prognostic significance according to tumour stage has yet to be evaluated. Therefore, the present study investigated fascin expression in 194 patients diagnosed with invasive ductal carcinoma of the breast between 2000 and 2005. Fascin protein expression levels were evaluated by immunostaining on a tissue microarray, and the association between fascin expression and various clinicopathological parameters was analysed. Fascin expression was significantly correlated with various clinicopathological parameters, including high histological grade, tumour necrosis, resistance to adjuvant therapy, high expression of p53 and Ki-67 and specific therapeutic markers (oestrogen and progesterone receptor negativity; all P<0.05). Furthermore, univariate and multivariate analyses identified a significant association between fascin expression, and poor disease-free and overall survival, in late-stage breast cancer (all P<0.05). Therefore, fascin may be crucial in predicting aggressive tumour behaviour, particularly in patients with advanced-stage disease that has acquired the properties of migration and invasion.
URI
https://www.spandidos-publications.com/10.3892/ol.2015.3191http://hdl.handle.net/20.500.11754/26640
ISSN
1792-1074; 1792-1082
DOI
10.3892/ol.2015.3191
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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