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dc.contributor.author민경환-
dc.date.accessioned2017-04-06T05:44:19Z-
dc.date.available2017-04-06T05:44:19Z-
dc.date.issued2015-07-
dc.identifier.citationONCOTARGET, v. 6, no. 19, page. 17276-17290en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttp://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=3640-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26639-
dc.description.abstractInhibitor of differentiation/DNA binding (Id) 1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in the mammary glands of MMTV-Id1 transgenic mice. Furthermore, MMTV-Id1 mice develop ductal hyperplasia and mammary tumors with highly expressed basal markers. Id1 also increases breast cancer stem cell (CSC) population and activity in human breast cancer lines. Moreover, the effects of Id1 on normal and malignant stem cell activities are mediated by the Wnt/c-Myc pathway. Collectively, these findings provide in vivo genetic evidence of Id1 functions as an oncogene in breast cancer and indicate that Id1 regulates mammary basal stem cells by activating the Wnt/c-Myc pathway, thereby contributing to breast tumor development.en_US
dc.description.sponsorshipThis study was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (No. 2010-0020879).en_US
dc.language.isoenen_US
dc.publisherIMPACT JOURNALS LLCen_US
dc.subjectbasal-like breast canceren_US
dc.subjectcancer stem cellen_US
dc.subjectId1en_US
dc.subjectmammary stem cellen_US
dc.subjectc-Mycen_US
dc.titleOverexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesisen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.3640-
dc.relation.journalONCOTARGET-
dc.contributor.googleauthorShin, Dong-Hui-
dc.contributor.googleauthorPark, Ji-Hye-
dc.contributor.googleauthorLee, Jeong-Yeon-
dc.contributor.googleauthorWon, Hee-Young-
dc.contributor.googleauthorJang, Ki-Seok-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.contributor.googleauthorJang, Si-Hyong-
dc.contributor.googleauthorWoo, Jong-Kyu-
dc.contributor.googleauthorOh, Seung Hyun-
dc.contributor.googleauthorKong, Gu-
dc.relation.code2015011641-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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