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SUVmax of F-18-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume

Title
SUVmax of F-18-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume
Author
지용배
Keywords
F-18-FDG PET/CT; Thyroid nodule; Thyroid cancer; Differential diagnosis; SUVmax
Issue Date
2015-07
Publisher
BIOMED CENTRAL LTD
Citation
WORLD JOURNAL OF SURGICAL ONCOLOGY, v. 13, Page. 217-222
Abstract
Background: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed. Methods: We studied 192 patients who underwent preoperative F-18-FDG PET/CT followed by thyroidectomy. We evaluated the correlation between the volume of thyroid nodules, F-18-FDG uptake on visual analysis, and the mean SUVmax measured on F-18-FDG PET/CT. Results: When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules ˃= 1 cm(3) (p ˂ 0.001). However, it did not differ between benign and malignant nodules smaller than 1 cm(3). At a cut-off value of SUVmax of 6, the respective sensitivities of F-18-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1 %, and the respective specificities were 95.9, 98.2, and 96.8 %. Conclusions: F-18-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.
URI
https://wjso.biomedcentral.com/articles/10.1186/s12957-015-0635-1http://hdl.handle.net/20.500.11754/26620
ISSN
1477-7819
DOI
10.1186/s12957-015-0635-1
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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