Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채필석 | - |
dc.date.accessioned | 2017-03-29T02:21:53Z | - |
dc.date.available | 2017-03-29T02:21:53Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | CHEMISTRY-A EUROPEAN JOURNAL, v. 21, NO 28, Page. 10008-10013 | en_US |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.issn | 1521-3765 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/chem.201501083/abstract | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26407 | - |
dc.description.abstract | Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and stabilise them in aqueous solutions. Conventional detergents are commonly used for membrane protein manipulation, but membrane proteins surrounded by these agents often undergo denaturation and aggregation. In this study, a novel class of maltoside-bearing amphiphiles, with a xylene linker in the central region, designated xylene-linked maltoside amphiphiles (XMAs) was developed. When these novel agents were evaluated with a number of membrane proteins, it was found that XMA-4 and XMA-5 have particularly favourable efficacy with respect to membrane protein stabilisation, indicating that these agents hold significant potential for membrane protein structural study. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean Government (MSIP; grant numbers 2008-0061891 and 2013R1A2A2A03067623 to P.S.C. and K.H.C.). The work was also supported by Biotechnology and Biological Sciences Research Council grant BB/K017292/1 to B.B. N.J.S. is the recipient of a BBSRC doctoral training programme studentship awarded to B.B. This work was supported by the National Science Foundation (grant MCB-1158085 to L.G.) and by the National Institutes of Health (grant R01 GM095538 to L.G.). C.J.L. is funded by the Danish Council for Independent Research Sapere Aude program, The Carlsberg Foundation and the UNIK center for Synthetic Biology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | amphiphile design | en_US |
dc.subject | membrane proteins | en_US |
dc.subject | detergents | en_US |
dc.subject | protein stabilisation | en_US |
dc.subject | protein structure | en_US |
dc.title | Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation | en_US |
dc.type | Article | en_US |
dc.relation.no | 28 | - |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.1002/chem.201501083 | - |
dc.relation.page | 10008-10013 | - |
dc.relation.journal | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.contributor.googleauthor | Cho, Kyung Ho | - |
dc.contributor.googleauthor | Du, Yang | - |
dc.contributor.googleauthor | Scull, Nicola J. | - |
dc.contributor.googleauthor | Hariharan, Parameswaran | - |
dc.contributor.googleauthor | Gotfryd, Kamil | - |
dc.contributor.googleauthor | Loland, Claus J. | - |
dc.contributor.googleauthor | Guan, Lan | - |
dc.contributor.googleauthor | Byrne, Bernadette | - |
dc.contributor.googleauthor | Kobilka, Brian K. | - |
dc.contributor.googleauthor | Chae, Pil Seok | - |
dc.relation.code | 2015002776 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | pchae | - |
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