annual lung function decline; chronic obstructive pulmonary disease; GOLD 2014
DOVE MEDICAL PRESS LTD
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 10, Page. 1819-1827
Background: Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups A-D were introduced, the lung function changes according to group have been evaluated rarely.
Objective: We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines.
Methods: Patients with COPD included in the Korean Obstructive Lung Disease (KOLD) prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1), which was analyzed by random-slope and random-intercept mixed linear regression.
Results: A total 175 participants were included. No significant postbronchodilator FEV1 decline was observed between the groups (-34.4 +/- 7.9 [group A]