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Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 이민형 | - |
| dc.date.accessioned | 2017-03-17T00:37:09Z | - |
| dc.date.available | 2017-03-17T00:37:09Z | - |
| dc.date.issued | 2015-07 | - |
| dc.identifier.citation | MACROMOLECULAR BIOSCIENCE, v. 15, NO 7, Page. 1021-1028 | en_US |
| dc.identifier.issn | 1616-5187 | - |
| dc.identifier.issn | 1616-5195 | - |
| dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201500058/full | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11754/26166 | - |
| dc.description.abstract | Heme oxygenase-1 (HO-1) has anti-apoptotic and anti-inflammatory effects. In this study, the HO-1 gene was delivered into the brain using dexamethasone-conjugated polyamidoamine generation 2 (PAMAMG2-Dexa) for the treatment of ischemic stroke. PAMAM G2-Dexa formed stable complexes with plasmid DNA (pDNA). The pDNA delivery efficiency of PAMAM G2-Dexa was higher than that of polyethylenimine (PEI25k, 25 kDa), dexamethasone-conjugated PEI (PEI-Dexa), and PAMAM G2 in Neuro2A cells. Therapeutic effect of PAMAM G2-Dexa/pHO-1 complexes was evaluated in a stroke animal model. PAMAM G2-Dexa delivered pHO-1 more efficiently into the ischemic brain than PEI25k and PEI-Dexa with higher therapeutic effect. Therefore, PAMAMG2-Dexa/pHO-1 complexes may be useful for ischemic stroke gene therapy. | en_US |
| dc.description.sponsorship | This work was financially supported by grants from the National Research Foundation of Korea, funded by the Ministry of Science, ICT, and Future Planning (grant number, NRF-2013R1A1A2059236). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
| dc.subject | dexamethasone | en_US |
| dc.subject | gene therapy | en_US |
| dc.subject | heme oxygenase-1 | en_US |
| dc.subject | polyamidoamine | en_US |
| dc.subject | stroke | en_US |
| dc.title | Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain | en_US |
| dc.type | Article | en_US |
| dc.relation.no | 7 | - |
| dc.relation.volume | 15 | - |
| dc.identifier.doi | 10.1002/mabi.201500058 | - |
| dc.relation.page | 1021-1028 | - |
| dc.relation.journal | MACROMOLECULAR BIOSCIENCE | - |
| dc.contributor.googleauthor | Jeon, Pureum | - |
| dc.contributor.googleauthor | Choi, Manbok | - |
| dc.contributor.googleauthor | Oh, Jungju | - |
| dc.contributor.googleauthor | Lee, Minhyung | - |
| dc.relation.code | 2015003024 | - |
| dc.sector.campus | S | - |
| dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
| dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
| dc.identifier.pid | minhyung | - |
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- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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