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20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activation

Title
20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activation
Author
이창호
Keywords
20(S)-protopanaxatriol; inflammatory mediators; mast cells; Panax ginseng
Issue Date
2015-07
Publisher
KOREAN SOC GINSENG
Citation
JOURNAL OF GINSENG RESEARCH, v. 39, NO 3, Page. 189-198
Abstract
Background: Antiallergic effect of 20(S)-protopanaxatriol (PPT), an intestinal metabolite of ginseng sa-ponins, was investigated in guinea pig lung mast cells and mouse bone marrow-derived mast cells activated by a specific antigen/antibody reaction. Methods: Increasing concentrations of PPT were pretreated 5 min prior to antigen stimulation, and various inflammatory mediator releases and their relevant cellular signaling events were measured in those cells. Results: PPT dose-dependently reduced the release of histamine and leukotrienes in both types of mast cells. Especially, in activated bone marrow-derived mast cells, PPT inhibited the expression of Syk protein, cytokine mRNA, cyclooxygenase-1/2, and phospholipase A(2) (PLA(2)), as well as the activities of various protein kinase C isoforms, mitogen-activated protein kinases, PLA(2), and transcription factors (nuclear factor-kappa B and activator protein-1). Conclusion: PPT reduces the release of inflammatory mediators via inhibiting multiple cellular signaling pathways comprising the Ca2+ influx, protein kinase C, and PLA(2), which are propagated by Syk activation upon allergic stimulation of mast cells. Copyright (C) 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1226845314001110http://hdl.handle.net/20.500.11754/26137
ISSN
1226-8453; 2093-4947
DOI
10.1016/j.jgr.2014.11.001
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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