Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat

Title
Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat
Authors
황세진
Keywords
Diabetic neuropathy; Granulocyte-colony stimulating factor; Bone marrow-derived cells
Issue Date
2015-07
Publisher
ELSEVIER IRELAND LTD
Citation
MOLECULAR AND CELLULAR ENDOCRINOLOGY, v. 414, NO C, Page. 64-72
Abstract
Effective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S030372071530023Xhttp://hdl.handle.net/20.500.11754/26120
ISSN
0303-7207
DOI
http://dx.doi.org/10.1016/j.mce.2015.07.014
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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