DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

Title
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
Authors
오영하
Keywords
EPITHELIAL-MESENCHYMAL TRANSITION; H3K79 METHYLATION; STEM-CELLS; C-MYC; SELF-RENEWAL; RECRUITMENT; LEUKEMIA; LINKS; PROLIFERATION; INHIBITION
Issue Date
2015-07
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v. 6, Page. 1-14
Abstract
DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progression. DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions. The upregulation of these EMT regulators by the DOT1L-c-Myc-p300 complex enhances EMT-induced breast cancer stem cell (CSC)-like properties. Furthermore, in vivo orthotopic xenograft models show that DOT1L is required for malignant transformation of breast epithelial cells and breast tumour initiation and metastasis. Clinically, DOT1L expression is associated with poorer survival and aggressiveness of breast cancers. Collectively, we suggest that cooperative effect of DOT1L and c-Myc-p300 is critical for acquisition of aggressive phenotype of breast cancer by promoting EMT/CSC.
URI
http://www.nature.com/articles/ncomms8821http://hdl.handle.net/20.500.11754/26087
ISSN
2041-1723
DOI
http://dx.doi.org/10.1038/ncomms8821
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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