Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer

Title
Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer
Authors
서용준
Keywords
Cytokines; epithelial-mesenchymal transition; PIM2; positive feedback loop; STAT3
Issue Date
2015-06
Publisher
WILEY-BLACKWELL
Citation
CANCER SCIENCE, v. 106, NO 6, Page. 718-725
Abstract
Metastasis of breast cancer is promoted by epithelial-mesenchymal transition (EMT). Emerging evidence suggests that STAT3 is a critical signaling node in EMT and is constitutively activated in many carcinomas, including breast cancer. However, its signaling mechanisms underlying persistent activation of STAT3 associated with EMT remain obscure. Here, we report that PIM2 promotes activation of STAT3 through induction of cytokines. Activation of STAT3 caused an increase in PIM2 expression, implicating a positive feedback loop between PIM2 and STAT3. In agreement, targeting of either PIM2, STAT3 or PIM2-dependent cytokines suppressed EMT-associated migratory and invasive properties through inhibition of ZEB1. Taken together, our findings identify the signaling mechanisms underlying the persistent activation of STAT3 and the oncogenic role of PIM2 in EMT in breast cancer.
URI
http://onlinelibrary.wiley.com/doi/10.1111/cas.12668/abstracthttp://hdl.handle.net/20.500.11754/25869
ISSN
1347-9032; 1349-700
DOI
http://dx.doi.org/10.1111/cas.12668
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RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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