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dc.contributor.author이동윤-
dc.date.accessioned2017-03-06T06:44:34Z-
dc.date.available2017-03-06T06:44:34Z-
dc.date.issued2015-06-
dc.identifier.citationBIOMATERIALS, v. 52, Page. 272-280en_US
dc.identifier.issn0142-9612-
dc.identifier.issn1878-5905-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0142961215001799-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25866-
dc.description.abstractThere is a clinical need for an alternative labeling agent for magnetic resonance imaging (MRI) in islet transplantation. We aimed to evaluate the feasibility of islet MRI using ferumoxytol, which is the only clinically-available ultrasmall superparamagnetic iron oxide. We compared islet function and viability of control islets and islets labeled with ferumoxytol and/or a heparin-protamine complex (HPF). Efficacy of ferumoxytol labeling was assessed in both ex vivo and in vivo models. Labeling for 48 h with HPF, but not up to 800 mu g/mL ferumoxytol, deranged ex vivo islet viability and function. The T2* relaxation time was optimal when islets were labeled with 800 mu g/mL of ferumoxytol for 48 h. Prussian blue stain, iron content assay, transmission electron microscopy (TEM) supported internalization of ferumoxytol particles. However, the labeling intensity in the ex vivo MRI of islets labeled with ferumoxytol was much weaker than that of islets labeled with ferucarbotran. In syngeneic intraportal islet transplantation, there was a correlation between the total area of visualized islets and the transplanted islet mass. In conclusion, islet MRI using ferumoxytol was feasible in terms of in vitro and in vivo efficacy and safety. However, the weak labeling efficacy is still a hurdle for the clinical application. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST; 2012R1A2A2A01013810, 2012R1A2A1A01012042). We received a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI12C1853). The authors of this manuscript have no conflicts of interest to disclose.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectIsleten_US
dc.subjectTransplantationen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNanoparticleen_US
dc.titleFeasibility of islet magnetic resonance imaging using ferumoxytol in intraportal islet transplantationen_US
dc.typeArticleen_US
dc.relation.volume52-
dc.identifier.doi10.1016/j.biomaterials.2015.02.055-
dc.relation.page272-280-
dc.relation.journalBIOMATERIALS-
dc.contributor.googleauthorJin, Sang-Man-
dc.contributor.googleauthorOh, Seung-Hoon-
dc.contributor.googleauthorOh, Bae Jun-
dc.contributor.googleauthorShim, Wooyoung-
dc.contributor.googleauthorChoi, Jin Myung-
dc.contributor.googleauthorYoo, Dongkyeom-
dc.contributor.googleauthorHwang, Yong Hwa-
dc.contributor.googleauthorLee, Jung Hee-
dc.contributor.googleauthorLee, Dong Yun-
dc.contributor.googleauthorKim, Jae Hyeon-
dc.relation.code2015001659-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.piddongyunlee-
dc.identifier.researcherIDH-4989-2012-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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