Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder

Title
Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder
Authors
이종민
Keywords
Attention-deficit hyperactivity disorder; cortical thickness; neuropsychology; phthalate
Issue Date
2015-06
Publisher
CAMBRIDGE UNIV PRESS
Citation
PSYCHOLOGICAL MEDICINE, v. 45, NO 8, Page. 1601-1612
Abstract
Background. Previous studies have implicated the relationship between environmental phthalate exposure and attention deficit hyperactivity disorder (ADHD) symptoms of childhood, but no studies have been conducted in children who have a confirmed diagnosis of ADHD obtained through meticulous diagnostic testing. We aimed to determine whether phthalate metabolites in urine would be higher in children with ADHD than in those without ADHD and would correlate with symptom severity and cortical thickness in ADHD children. Method. A cross-sectional examination of urine phthalate metabolite concentrations was performed; scores for ADHD symptoms, externalizing problems, and continuous performance tests were obtained from 180 children with ADHD, and brain-imaging data were obtained from 115 participants. For the control group, children without ADHD (N = 438) were recruited. Correlations between phthalate metabolite concentrations and clinical measures and brain cortical thickness were investigated. Results. Concentrations of phthalate metabolites, particularly the di(2-ethylhexyl) phthalate (DEHP) metabolite, were significantly higher in boys with ADHD than in boys without ADHD. Concentrations of the di-n-butyl phthalate (DBP) metabolite were significantly higher in the combined or hyperactive-impulsive subtypes compared to the inattentive subtype, and the metabolite was positively correlated with the severity of externalizing symptoms. Concentrations of the DEHP metabolite were negatively correlated with cortical thickness in the right middle and superior temporal gyri. Conclusions. The results of this study suggest an association between phthalate concentrations and both the diagnosis and symptom severity of ADHD. Imaging findings suggest a negative impact of phthalates on regional cortical maturation in children with ADHD.
URI
https://www.cambridge.org/core/journals/psychological-medicine/article/div-classtitleassociation-between-phthalates-and-externalizing-behaviors-and-cortical-thickness-in-children-with-attention-deficit-hyperactivity-disorderdiv/3080F4E0682FBEB7DCA966E26711A45Bhttp://hdl.handle.net/20.500.11754/25827
ISSN
0033-2917; 1469-8978
DOI
http://dx.doi.org/10.1017/S0033291714002694
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ETC
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