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EGFR negates the proliferative effect of oncogenic HER2 in MDA-MB-231 cells

Title
EGFR negates the proliferative effect of oncogenic HER2 in MDA-MB-231 cells
Author
신인철
Keywords
EGFR; HER2; Triple negative breast cancer; Breast cancer cell
Issue Date
2015-06
Publisher
ELSEVIER SCIENCE INC
Citation
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v. 575, Page. 69-76
Abstract
Members of the EGFR family are potent mediators of normal cell growth and development. HER2 possesses an active tyrosine kinase domain, but no direct ligand has been identified. To investigate the differential effect of HER2 in breast cell lines, HER2 was overexpressed in MCF-10A, MCF7 and MDA-MB-231 cells. HER2 overexpression promoted proliferation, survival and migration in MCF-10A and MCF-7 cells. No significant differences were seen in proliferation, survival or migration between MDA-MB-231 vec and HER2 cells. The activity of downstream HER2 proteins increased in MCF-10A HER2 and MCF-7 HER2 cells but not in MDA-MB-231 HER2 cells. Exogenously expressed HER2 failed to associate with EGFR or HER3 in MDA-MB-231 cells, while overexpression of HER2 enhanced HER family dimerization in MCF-10A and MCF-7 cells. (C) 2015 Published by Elsevier Inc.
URI
http://www.sciencedirect.com/science/article/pii/S000398611500209Xhttp://hdl.handle.net/20.500.11754/25813
ISSN
0003-9861; 1096-0384
DOI
10.1016/j.abb.2015.04.008
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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