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dc.contributor.author노재숙-
dc.date.accessioned2017-02-27T02:47:33Z-
dc.date.available2017-02-27T02:47:33Z-
dc.date.issued2015-06-
dc.identifier.citationJOURNAL OF ANATOMY, v. 227, Page. 10-20en_US
dc.identifier.issn1469-7580-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/joa.12332/abstract-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25695-
dc.description.abstractCaffeine adversely affects endochondral ossification during fetal skeletal growth, and results in increased incidence of delayed and abnormal fetal skeletal development. Chronic caffeine intake also decreases growth hormone secretion. Thus, it is conceivable that caffeine may disrupt bone growth during the peripubertal period. This study aimed to investigate the impact of high-caffeine consumption on bone growth throughout puberty. A total of 51 male rats (21days old) were divided randomly into three groups: a control group and two groups fed caffeine via gavage with 120 and 180mgkg(-1)day(-1) for 4weeks. After death, the final length and weight of leg bones were measured, and the tibia processed for histomorphometric analysis. Caffeine caused a significant decrease in body mass gain. This was accompanied with proportional decreases in lean body mass and body fat. In addition, bone mass and osteogenic activity invivo were assessed using dual-energy X-ray absorptiometry and F-18-NaF positron emission tomography. The results showed significant decreases of bone mass and invivo osteogenic activity in the caffeine-fed groups. Rats fed with caffeine showed a significantly shorter and lighter tibia and femur and the vertebral column compared with controls. In addition, caffeine does not increase the width of the growth plates (GPs), it slows the rate at which the GP closes due to a slower rate of growth. These results demonstrated that caffeine altered osteogenic activity, leading to delayed peripubertal longitudinal bone growth and maturation. Given that osteogenic cells undergo dynamic changes in metabolic activity and that the pubertal growth spurt is mainly stimulated by growth hormone/insulin-like growth factor-1 and sex steroids during pubertal development, caffeine could suppress ossification by interfering with both physiological changes in hormonal secretion and osteogenic activity during this critical period. Further study will be needed to investigate the cellular/molecular mechanism by which caffeine affects osteogenesis using invitro experimental models.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education and Science (NRF-2013R1A1A3006054, 2014R1A1A2053601). All authors state that they have no conflicts of interest.en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subject18F‐NaF PETen_US
dc.subjectcaffeineen_US
dc.subjectDXAen_US
dc.subjectgrowth spurten_US
dc.subjectosteogenesisen_US
dc.subjectpubertyen_US
dc.titleHigh doses of caffeine reduce in vivo osteogenic activity in prepubertal ratsen_US
dc.typeArticleen_US
dc.relation.volume227-
dc.identifier.doi10.1111/joa.12332-
dc.relation.page10-20-
dc.relation.journalJOURNAL OF ANATOMY-
dc.contributor.googleauthorShin, Jiwon-
dc.contributor.googleauthorChoi, Yuri-
dc.contributor.googleauthorKim, Jisook-
dc.contributor.googleauthorYu, A-Ram-
dc.contributor.googleauthorShin, JiSoo-
dc.contributor.googleauthorChoi, YunYoung-
dc.contributor.googleauthorRoh, Jaesook-
dc.relation.code2015002269-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidrohjaesook-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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