Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma

Title
Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma
Authors
김경래
Keywords
Polymorphism; SNP; ADH1B; ADH1C; Head and neck cancer
Issue Date
2015-06
Publisher
SPRINGER
Citation
TUMOR BIOLOGY, v. 36, NO 6, Page. 4387-4396
Abstract
Alcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely -992C ˃ G, -957C ˃ A, +3170A ˃ G, +3377G ˃ T, +3491G ˃ A, and +13543A ˃ G, and five SNPs of ADH1C, namely -1064C ˃ T, -325G ˃ C, +5702A ˃ G, +7462T ˃ C, and +13044A ˃ G, in 260 Korean HNSCC patients and 330 controls, using single base extension and the TaqMan assay. The odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the CG and GG genotypes of ADH1B -992C ˃ G, the AA genotype of -957C ˃ A, the GG genotype of +3170A ˃ G, the GA genotype of +3491G ˃ A, and +13543A ˃ G were 0.51 (0.32-0.82), 0.63 (0.42-0.94), 1.84 (1.13-2.99), 1.77 (1.15-2.73), 2.34 (1.44-3.79), and 2.21 (1.23-3.95), respectively. The ORs of ADH1C +13044A ˃ G were 1.94 (1.01-3.71) and 1.97 (1.05-3.71) in the dominant and co-dominant models, respectively. The ORs of the GC genotype of ADH1C -325G ˃ C and the AG genotype of +5702A ˃ G were 2.52 (1.51-4.21) and 2.43 (1.36-4.32), respectively. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G were in strong linkage disequilibrium with the other SNPs of ADH1B and ADH1C, respectively. There were gene-environment interactions between ADH1B +3170A ˃ G and ADH1C +13044A ˃ G and alcohol consumption and smoking. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G SNPs are associated with an increased risk of HNSCC, and they could be used as biomarkers for the high-risk group of HNSCC in Koreans.
URI
http://link.springer.com/article/10.1007%2Fs13277-015-3078-yhttp://hdl.handle.net/20.500.11754/25559
ISSN
1010-4283; 1423-0380
DOI
http://dx.doi.org/10.1007/s13277-015-3078-y
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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