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dc.contributor.author채필석-
dc.date.accessioned2017-02-15T06:36:56Z-
dc.date.available2017-02-15T06:36:56Z-
dc.date.issued2015-06-
dc.identifier.citationRSC ADVANCES, v. 5, no. 57, Page. 46276-46281en_US
dc.identifier.issn2046-2069-
dc.identifier.urihttp://pubs.rsc.org/en/content/articlehtml/2015/ra/c5ra03872c-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25524-
dc.description.abstractThis study introduces a robust approach for the fabrication of extremely stable oil-in-water nanoemulsions in which the interface is stabilized by assembly of amphiphilic poly(ethylene oxide)-block-poly(3-caprolactone) (PEO-b-PCL) copolymers. Phase inversion emulsification, induced by variation of the water volume fraction, facilitated effective assembly of the block copolymers at the oil-water interface. Subsequent application of simple probe-type sonication reduced the droplet size of the precursor emulsions to approximately 200 nm. The prepared nanoemulsions were surprisingly stable against drop coalescence and aggregation, as confirmed by analysis of changes in the droplet size after repeated freeze-thaw cycling and by monitoring the creaming kinetics under conditions of high ionic strength and density mismatch. The results highlight that good structural assembly of the PEO-b-PCL block copolymers at the oil-water interface generated a mechanically flexible but tough polymer film, thereby remarkably improving the emulsion stability.en_US
dc.description.sponsorshipThis work was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant no.: A103017). This research was also supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A2039).en_US
dc.language.isoenen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.subjectPEO TRIBLOCK COPOLYMERSen_US
dc.subjectPHASE INVERSION TEMPERATUREen_US
dc.subjectNANO-EMULSIONSen_US
dc.subjectBLOCK-COPOLYMERSen_US
dc.subjectTOPICAL DELIVERYen_US
dc.subjectEMULSIFICATIONen_US
dc.subjectPOINTen_US
dc.subjectMICROEMULSIONSen_US
dc.subjectNANOEMULSIONSen_US
dc.subjectTRANSITIONen_US
dc.titleFabrication and stabilization of nanoscale emulsions by formation of a thin polymer membrane at the oil-water interfaceen_US
dc.typeArticleen_US
dc.relation.volume5-
dc.identifier.doi1039/c5ra03872c-
dc.relation.page46276-46281-
dc.relation.journalRSC ADVANCES-
dc.contributor.googleauthorShin, Kyounghee-
dc.contributor.googleauthorKim, Jeong Won-
dc.contributor.googleauthorPark, Hanhee-
dc.contributor.googleauthorChoi, Hong Sung-
dc.contributor.googleauthorChae, Pil Seok-
dc.contributor.googleauthorNam, Yoon Sung-
dc.contributor.googleauthorKim, Jin Woong-
dc.relation.code2015011569-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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