Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies

Title
Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies
Author
정진환
Keywords
ACUTE ISCHEMIC-STROKE; PLASMA COPEPTIN; BRAIN EDEMA; INTRACEREBRAL HEMORRHAGE; SUBARACHNOID HEMORRHAGE; CEREBRAL-ISCHEMIA; V-2 RECEPTORS; VASOPRESSIN; MORTALITY; BIOMARKERS
Issue Date
2015-06
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 5, Page. 1-12
Abstract
Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.
URI
http://www.nature.com/articles/srep11665http://hdl.handle.net/20.500.11754/25183
ISSN
2045-2322
DOI
10.1038/srep11665
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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