Association study of polymorphisms in interferon-gamma receptor genes with the risk of pulmonary tuberculosis

Title
Association study of polymorphisms in interferon-gamma receptor genes with the risk of pulmonary tuberculosis
Authors
고인송
Keywords
single nucleotide polymorphism; interferon- receptor 1; interferon- receptor 2; tuberculosis
Issue Date
2015-06
Publisher
SPANDIDOS PUBL LTD
Citation
MOLECULAR MEDICINE REPORTS, v. 12, NO 1, Page. 1568-1578
Abstract
Tuberculosis (TB) is an infectious disease caused by mycobacterium, which most commonly affects the lungs. The adaptive immune response in Mycobacterium tuberculosis is predominantly mediated by the interferon- (IFN-) signaling pathway, which is regulated by IFN- receptors (IFNGR). IFN- activates the transcription of a number of genes that are important in immune responses, thus the appropriate function of IFNGR appears to be important in host defense against mycobacteria. In the present study, 22 genetic variants in IFNGR1 and IFNGR2 were genotyped in 673 patients and 592 normal controls to investigate the association between IFNGR1 and IFNGR2 polymorphisms and the risk of TB. Statistical analyses revealed that four genetic variants in IFNGR1, rs9376269, rs9376268, rs9376267 and rs56251346 were marginally associated with the risk of TB (P=0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 and IFNGR2 did not exhibit any associations. However, the significance of the four genetic variants rs9376269, rs9376268, rs9376267 and rs56251346 was eliminated following a multiple testing correction of the data (P˃0.05). The present results revealed that certain genetic variants in IFNGR genes may be associated with TB development, which may be useful preliminary data for future investigation.
URI
https://www.spandidos-publications.com/10.3892/mmr.2015.3544http://hdl.handle.net/20.500.11754/25159
ISSN
1791-2997; 1791-3004
DOI
http://dx.doi.org/10.3892/mmr.2015.3544
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE