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dc.contributor.author안주홍-
dc.date.accessioned2017-01-16T01:35:20Z-
dc.date.available2017-01-16T01:35:20Z-
dc.date.issued2015-06-
dc.identifier.citationTOXINS, v. 7, NO 7, Page. 2435-2453en_US
dc.identifier.issn2072-6651-
dc.identifier.urihttp://www.mdpi.com/2072-6651/7/7/2435-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25143-
dc.description.abstractBotulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including glutamate, substance P (SP), and calcitonin gene-related peptide (CGRP), as well as the addition of pain-sensing transmembrane receptors such as transient receptor potential (TRP) to neuronal plasma membrane. In addition, growing evidence suggests that the analgesic and anti-inflammatory effects of BoNTs are mediated through various molecular pathways. Recent studies have revealed that the detailed structural bases of BoNTs interact with their cellular receptors and SNAREs. In this review, we discuss the molecular and cellular mechanisms related to the efficacy of BoNTs in alleviating human pain and insights on engineering the toxins to extend therapeutic interventions related to nociception.en_US
dc.description.sponsorshipThis work was supported by the Women Scientist program (No. 2013R1A1A3A04006010) and Basic Science Research Program (2013R1A1A2005836) through the National Research Foundation of Korea (NRF) funded by Korean Ministry of Science, ICT & Future Planning.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.subjectbotulinum neurotoxinen_US
dc.subjectpainen_US
dc.subjectnociceptionen_US
dc.subjectneurotransmitteren_US
dc.subjectneuropeptideen_US
dc.subjectTRPen_US
dc.titleBotulinum Toxin as a Pain Killer: Players and Actions in Antinociceptionen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume7-
dc.identifier.doi10.3390/toxins7072435-
dc.relation.page2435-2453-
dc.relation.journalTOXINS-
dc.contributor.googleauthorKim, Dong-Wan-
dc.contributor.googleauthorLee, Sun-Kyung-
dc.contributor.googleauthorAhnn, Joohong-
dc.relation.code2015013958-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjoohong-


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