Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception

Title
Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception
Author
안주홍
Keywords
botulinum neurotoxin; pain; nociception; neurotransmitter; neuropeptide; TRP
Issue Date
2015-06
Publisher
MDPI AG
Citation
TOXINS, v. 7, NO 7, Page. 2435-2453
Abstract
Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including glutamate, substance P (SP), and calcitonin gene-related peptide (CGRP), as well as the addition of pain-sensing transmembrane receptors such as transient receptor potential (TRP) to neuronal plasma membrane. In addition, growing evidence suggests that the analgesic and anti-inflammatory effects of BoNTs are mediated through various molecular pathways. Recent studies have revealed that the detailed structural bases of BoNTs interact with their cellular receptors and SNAREs. In this review, we discuss the molecular and cellular mechanisms related to the efficacy of BoNTs in alleviating human pain and insights on engineering the toxins to extend therapeutic interventions related to nociception.
URI
http://www.mdpi.com/2072-6651/7/7/2435http://hdl.handle.net/20.500.11754/25143
ISSN
2072-6651
DOI
10.3390/toxins7072435
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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