Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease

Title
Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease
Authors
이종민
Keywords
Parkinson's disease; resting state functional connectivity; olfaction; cognition
Issue Date
2015-05
Publisher
WILEY-BLACKWELL
Citation
HUMAN BRAIN MAPPING, v. 36, NO 5, Page. 1716-1727
Abstract
Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naive patients with PD were subdivided into three groups of high score (PD-H, n=23), middle score (PD-M, n=64), and low score (PD-L, n=23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD. Hum Brain Mapp 36:1716-1727, 2015.
URI
http://onlinelibrary.wiley.com/doi/10.1002/hbm.22732/abstract;jsessionid=523D53BA5CA76A4946AAD9EFF618F8E7.f03t02http://hdl.handle.net/20.500.11754/24985
ISSN
1065-9471; 1097-0193
DOI
http://dx.doi.org/10.1002/hbm.22732
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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