Graphene oxide-encoded Ag nanoshells with single-particle detection sensitivity towards cancer cell imaging based on SERRS

Title
Graphene oxide-encoded Ag nanoshells with single-particle detection sensitivity towards cancer cell imaging based on SERRS
Authors
주재범
Keywords
ENHANCED RAMAN-SCATTERING; TURN-ON RESPONSE; BIOMEDICAL APPLICATIONS; NANOPARTICLE PROBES; SILVER NANOSHELLS; SPECTROSCOPY; NANOPROBES; MICROSCOPY; MOLECULE; TAGS
Issue Date
2015-05
Publisher
ROYAL SOC CHEMISTRY
Citation
ANALYST, v. 140, Page. 3362-3367
Abstract
Developing ultrasensitive Raman nanoprobes is one of the emerging interests in the field of biosensing and bioimaging. Herein, we constructed a new type of surface-enhanced resonance Raman scattering nanoprobe composed of an Ag nanoshell as a surface-enhanced Raman scattering-active nanostructure, which was encapsulated with 4,7,10-trioxa-1,13-tridecanediamine-functionalized graphene oxide as an ultrasensitive Raman reporter exhibiting strong resonance Raman scattering including distinct D and G modes. The designed nanoprobe was able to produce much more intense and simpler Raman signals even at a single particle level than the Ag nanoshell bearing a well-known Raman reporter, which is beneficial for the sensitive detection of a target in a complex biological system. Finally, this ultrasensitive nanoprobe successfully demonstrated its potential for bioimaging of cancer cells using Raman spectroscopy.
URI
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C4AN02382J#!divAbstracthttp://hdl.handle.net/20.500.11754/24964
ISSN
0003-2654; 1364-5528
DOI
http://dx.doi.org/10.1039/c4an02382j
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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