Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-01-06T05:13:00Z | - |
dc.date.available | 2017-01-06T05:13:00Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | GENETICS AND MOLECULAR RESEARCH, v. 14, NO 2, Page. 5548-5559 | en_US |
dc.identifier.issn | 1676-5680 | - |
dc.identifier.uri | http://www.funpecrp.com.br/gmr/year2015/vol14-2/pdf/gmr5106.pdf | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24951 | - |
dc.description.abstract | We investigated whether the tumor necrosis factor-alpha (TNF-alpha) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-alpha polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to examine the associations between the TNF-alpha -238 A/G polymorphism and RA and vitiligo using the allelic contrast and dominant models. Fifteen studies (10 RA and 5 vitiligo) involving 3678 cases and 4400 controls were considered. We observed an association between the TNF-alpha -238 A allele and RA when all subjects were considered [odds ratio (OR) = 0.686, 95% confidence interval (CI) = 0.476-0.968, P = 0.043]. After stratification by ethnicity, we found no association between the TNF-alpha -238 A allele and RA in European or Asian populations. We observed no association between the TNF-alpha -308 A allele and vitiligo (OR = 1.787, 95% CI = 0.894-3.573, P = 0.101). However, the adjusted OR by the trim-and-fill technique was significant (OR = 2.064, 95%CI = 1.138-3.743). After stratification by geographic continent, the TNF-alpha -308 A allele was significantly associated with vitiligo in Middle Eastern populations (OR = 1.569, 95%CI = 1.224-2.013, P = 3.8 x 10(-5)). The TNF-alpha -238 A/G polymorphism was associated with RA susceptibility, and the TNF-alpha -308 A/G polymorphism may be a significant risk factor for vitiligo in Middle Eastern populations. | en_US |
dc.description.sponsorship | Research supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (#HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | FUNPEC-EDITORA | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Tumor necrosis factor | en_US |
dc.subject | Vitiligo | en_US |
dc.title | Associations between TNF-alpha polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.4238/2015.May.25.6 | - |
dc.relation.page | 5548-5559 | - |
dc.relation.journal | GENETICS AND MOLECULAR RESEARCH | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S. C. | - |
dc.relation.code | 2015011233 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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