Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis

Title
Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis
Authors
배상철
Keywords
Systemic lupus erythematosus; Rheumatoid arthritis; ITGAM; Polymorphism; Meta-analysis
Issue Date
2015-05
Publisher
SPRINGER HEIDELBERG
Citation
RHEUMATOLOGY INTERNATIONAL, v. 35, NO 5, Page. 815-823
Abstract
The aim of this study was to determine whether the functional integrin-alpha-M (ITGAM) rs1143679 polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), lupus nephritis (LN), and rheumatoid arthritis (RA). A series of meta-analyses were conducted to test for associations between the ITGAM rs1143679 polymorphism and SLE, LN, or RA. A total of 24 comparisons involving 7,738 patients and 8,309 controls for SLE, and 2,663 patients and 2,694 controls in RA were considered. Meta-analysis showed a significant association between the ITGAM rs1143679 A allele and SLE in all subjects (OR 1.773, 95 % CI 1.656, 1.901, p ˂ 1.0 x 10(-9)). After stratification by ethnicity, the A allele was found to be significantly associated with SLE in European, Latin American, and Asian. A significant association was also found between the ITGAM A allele and lupus nephritis in Europeans (OR 2.131, 95 % CI 1.565, 2.903, p = 1.6 x 10(-7)). However, no association was found between RA and the ITGAM rs1143679 polymorphism. Our meta-analyses confirm that the ITGAM rs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European.
URI
http://link.springer.com/article/10.1007%2Fs00296-014-3156-2http://hdl.handle.net/20.500.11754/24949
ISSN
0172-8172; 1437-160X
DOI
http://dx.doi.org/10.1007/s00296-014-3156-2
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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