Cell sources, liver support systems and liver tissue engineering: Alternatives to liver transplantation

Title
Cell sources, liver support systems and liver tissue engineering: Alternatives to liver transplantation
Authors
김한준
Keywords
Hepatocyte; Stem cells; Liver; Bioartificial liver; Liver tissue engineering; Bioprinting
Issue Date
2015-05
Publisher
Korean Society for Stem Cell Research
Citation
International Journal of Stem Cells, v. 8, NO 1, Page. 36-47
Abstract
The liver is the largest organ in the body; it has a complex architecture, wide range of functions and unique regenerative capacity. The growing incidence of liver diseases worldwide requires increased numbers of liver transplant and leads to an ongoing shortage of donor livers. To meet the huge demand, various alternative approaches are being investigated including, hepatic cell transplantation, artificial devices and bioprinting of the organ itself. Adult hepatocytes are the preferred cell sources, but they have limited availability, are difficult to isolate, propagate poor and undergo rapid functional deterioration in vitro. There have been efforts to overcome these drawbacks; by improving culture condition for hepatocytes, providing adequate extracellular matrix, co-culturing with extra-parenchymal cells and identifying other cell sources. Differentiation of human stem cells to hepatocytes has become a major interest in the field of stem cell research and has progressed greatly. At the same time, use of decellularized organ matrices and 3 D printing are emerging cutting-edge technologies for tissue engineering, opening up new paths for liver regenerative medicine. This review provides a compact summary of the issues, and the locations of liver support systems and tissue engineering, with an emphasis on reproducible and useful sources of hepatocytes including various candidates formed by differentiation from stem cells.
URI
http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc.2015.8.1.36http://hdl.handle.net/20.500.11754/24863
ISSN
2005-3606; 2005-5447
DOI
http://dx.doi.org/10.15283/ijsc.2015.8.1.36
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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