Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer

Title
Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer
Authors
이강녕
Keywords
Obesity; Visceral fat area; Lymph node; Metastasis; Colon cancer
Issue Date
2015-05
Publisher
SPRINGER
Citation
JOURNAL OF GASTROINTESTINAL SURGERY, v. 19, NO 8, Page. 1513-1521
Abstract
The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Metastatic LN ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected LNs. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) ˃ 0.29. In a multivariate analysis among 186 patients, there were inverse associations between V/T and MLR (OR = 0.413, 95 % CI = 0.216-0.789, P = 0.007). Furthermore, patients with visceral obesity tended to have significantly better OS than patients with non-visceral obesity. Higher V/T ratios which indicate referring to visceral obesity was significantly associated with decreased MLR and better OS for CRC.
URI
http://link.springer.com/article/10.1007%2Fs11605-015-2834-zhttp://hdl.handle.net/20.500.11754/24836
ISSN
1091-255X; 1873-4626
DOI
http://dx.doi.org/10.1007/s11605-015-2834-z
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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