Vascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic pain

Title
Vascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic pain
Authors
이민형
Keywords
neural stem cells; neuropathic pain; sciatic nerve injury; vascular endothelial growth factor
Issue Date
2015-05
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
NEUROREPORT, v. 26, NO 7, Page. 399-404
Abstract
Previously, we determined that vascular endothelial growth factor (VEGF) improves the survival of neural stem cells (NSCs) transplanted into an ischemic environment and effectively enhances angiogenesis. Here, we applied NSCs expressing VEGF (SV-VEGF-NSCs) to treat neuropathic pain. In this study, our goal was to verify the therapeutic effect of SV-VEGF-NSCs by transplanting the cells in a sciatic nerve injury model. We compared the amount of VEGF secreted from DsRed-NSCs (control) or SV-VEGF-NSCs and observed that SV-VEGF-NSCs have a much higher expression level of VEGF. We next investigated whether transplantation with SV-VEGF-NSCs aids functional recovery and pain reduction. We confirmed that transplantation with SV-VEGF-NSCs enhances functional recovery, pain reduction, and remyelination as well as the number of blood vessels compared with the control groups. Our results show that VEGF aids functional recovery and pain reduction in a sciatic nerve injury model. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
URI
http://ovidsp.tx.ovid.com/sp-3.23.1b/ovidweb.cgi?QS2=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://hdl.handle.net/20.500.11754/24821
ISSN
0959-4965; 1473-558X
DOI
http://dx.doi.org/10.1097/WNR.0000000000000359
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE