Microfabrication of Custom Collagen Structures Capable of Guiding Cell Morphology and Alignment

Title
Microfabrication of Custom Collagen Structures Capable of Guiding Cell Morphology and Alignment
Author
Jaworski
Issue Date
2015-05
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v. 16, NO 6, Page. 1761-1770
Abstract
The patterning of biological components into structural analogues of native tissues to simulate an environment for directing cell growth is one important strategy in biomaterials fabrication. It is widely accepted that chemical, mechanical, and topological cues from the extracellular matrix (ECM) provide important signals for guiding cells to exhibit characteristic polarity, orientation, and morphology. To fully understand the delicate relationship between cell behavior and ECM features, biomaterials fabrication requires improved techniques for tailoring nano/microstructured patterns from relevant biological building blocks rather than using nonbiological materials. Here we reveal a unique approach for the nano/microfabrication of custom patterned biomaterials using collagen as the sole building material. With this new fabrication technique, we further revealed that custom collagen patterns could direct the orientation and morphology of fibroblast growth as a function of vertex density and pattern spacing. Our findings suggest that this technique may be readily adopted for the free form fabrication of custom cell scaffolds purely from natural biological molecules including collagen, among other relevant ECM components.
URI
http://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b00295http://hdl.handle.net/20.500.11754/24780
ISSN
1525-7797; 1526-4602
DOI
10.1021/acs.biomac.5b00295
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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