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dc.contributor.author문지용-
dc.date.accessioned2016-12-02T00:16:22Z-
dc.date.available2016-12-02T00:16:22Z-
dc.date.issued2015-05-
dc.identifier.citationJOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, NO 2, Page. 155-161en_US
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttp://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2015.30.2.155-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24656-
dc.description.abstractThe Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, and polarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation and cancer, and loss of Wnt7a expression has been demonstrated in lung cancer cell lines. E-cadherin keeps intercellular integrity and prevents metastasis. Therefore, E-cadherin has been known as a prognostic factor in cancer. In the present study, we investigated the E-cadherin expression status by immunohistochemical stain and the Wnt7a promoter methylation status in human non-small cell lung carcinoma (NSCLC) by methylation-specific PCR. We also analyzed their correlations with clinicopathological factors. Methylation of the Wnt7a gene promoter was detected in the lung tissues of 32 of 121 (26.4%) patients with NSCLC. Wnt7a promoter methylation was correlated with advanced tumor stage (P=0.036) and distant metastasis (P=0.037). In addition, Wnt7a promoter methylation showed correlation with loss of E-cadherin expression (P˂0.001). However, Wnt7a promoter methylation was not closely related with gender, age, histological type, or smoking habit. Even though Wnt7a methylation could not show significant correlation with the long term survival of the patients with limited follow up data, these findings suggest that loss of the Wnt7a gene induced by promoter methylation might be another prognostic factor for NSCLC and that restoration of Wnt7a may be a promising treatment for NSCLC.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2011-I).en_US
dc.language.isoenen_US
dc.publisherKOREAN ACAD MEDICAL SCIENCESen_US
dc.subjectCarcinomaen_US
dc.subjectNon-small Cell Lungen_US
dc.subjectWnt7aen_US
dc.subjectBiologic Markersen_US
dc.subjectE-cadherinen_US
dc.titleClinical Significance of Aberrant Wnt7a Promoter Methylation in Human Non-Small Cell Lung Cancer in Koreansen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume30-
dc.identifier.doi10.3346/jkms.2015.30.2.155-
dc.relation.page155-161-
dc.relation.journalJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.contributor.googleauthorKim, Tae-Hyung-
dc.contributor.googleauthorMoon, Ji-Yong-
dc.contributor.googleauthorKim, Sang-Heon-
dc.contributor.googleauthorPaik, Seung Sam-
dc.contributor.googleauthorYoon, Ho Joo-
dc.contributor.googleauthorShin, Dong Ho-
dc.contributor.googleauthorPark, Sung Soo-
dc.contributor.googleauthorSohn, Jang Won-
dc.relation.code2015003059-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmoonji-
dc.identifier.orcidhttp://orcid.org/0000-0003-2459-3448-


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