Cationic cell-penetrating peptides as vehicles for siRNA delivery

Title
Cationic cell-penetrating peptides as vehicles for siRNA delivery
Author
이상경
Issue Date
2015-04
Publisher
Future Science
Citation
Therapeutic delivery, v. 6, NO 4, Page. 491-507
Abstract
RNA interference mediated gene silencing has tremendous applicability in fields ranging from basic biological research to clinical therapy. However, delivery of siRNA across the cell membrane into the cytoplasm, where the RNA silencing machinery is located, is a significant hurdle in most primary cells. Cell-penetrating peptides (CPPs), peptides that possess an intrinsic ability to translocate across cell membranes, have been explored as a means to achieve cellular delivery of siRNA. Approaches using CPPs by themselves or through incorporation into other siRNA delivery platforms have been investigated with the intent of improving cytoplasmic delivery. Here, we review the utilization of CPPs for siRNA delivery with a focus on strategies developed to enhance cellular uptake, endosomal escape and cytoplasmic localization of CPP/siRNA complexes. © 2015 Future Science Ltd.
URI
http://www.future-science.com/doi/10.4155/tde.15.2http://hdl.handle.net/20.500.11754/24125
ISSN
2041-5990; 2041-6008
DOI
10.4155/tde.15.2
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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