Sarcopenia is a risk factor for elevated aminotransferase in men independently of body mass index, dietary habits, and physical activity

Title
Sarcopenia is a risk factor for elevated aminotransferase in men independently of body mass index, dietary habits, and physical activity
Author
이항락
Keywords
Alanine aminotransferase; Aspartate aminotransferase; Muscle mass; Sarcopenia; Skeletal muscle index
Issue Date
2015-04
Publisher
ELSEVIER SCIENCE INC
Citation
DIGESTIVE AND LIVER DISEASE, v. 47, NO 4, Page. 303-308
Abstract
Background: Aminotransferase activity is a surrogate marker of liver injury showing strong correlations with obesity and metabolic syndrome. However, elevated aminotransferase activity is not uncommon in non-obese and non-alcoholic patients in clinical practice. Aim: To examine the relationship between sarcopenia and aminotransferase activity in a large population-based cohort. Methods: Data from the Korean National Health and Nutrition Examinations were used. A total of 13,431 subjects were included. A whole-body dual X-ray absorptiometry scan was performed on each patient to measure total and regional muscle mass. Appendicular skeletal muscle mass indices were also obtained. Results: The prevalence of sarcopenia was significantly higher in the group with elevated aminotransferase levels than in the normal liver enzyme group (males: 26.5% vs. 16.9%; females: 38.3% vs. 22.1%, p < 0.05). The skeletal muscle index was negatively correlated with most cardiometabolic risk factors, including fasting glucose and cholesterol levels. The frequency of elevated aminotransferase increased in male patients with sarcopenia after adjusting for potential confounding factors including age, body mass index, fasting glucose level, dietary, and exercise habits. However, the correlation was no longer observed in women after adjusting for body mass index. Conclusion: Sarcopenia is a risk factor for elevated aminotransferase in men, independently of body mass index, dietary habits, and physical activity. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1590865814008469http://hdl.handle.net/20.500.11754/24121
ISSN
1590-8658; 1878-3562
DOI
10.1016/j.dld.2014.12.014
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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