404 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이종민-
dc.date.accessioned2016-11-02T06:37:24Z-
dc.date.available2016-11-02T06:37:24Z-
dc.date.issued2015-04-
dc.identifier.citationEUROPEAN JOURNAL OF NEUROLOGY, v. 22, NO 4, Page. 709-716en_US
dc.identifier.issn1351-5101-
dc.identifier.issn1468-1331-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/ene.12645/abstract-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24085-
dc.description.abstractBackground and purposeRecent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease pathologies. Therefore, our aim was to evaluate the divergent topography of WM microstructural changes in patients with pure AD and SVaD. MethodsPatients who were clinically diagnosed with AD and SVaD were prospectively recruited. Forty AD patients who were Pittsburgh compound B (PiB) positive [PiB(+) AD] without WM hyperintensities and 32 SVaD patients who were PiB negative [PiB(-) SVaD] were chosen. Fifty-six cognitively normal individuals were also recruited (NC). Tract-based spatial statistics of diffuse tensor imaging were used to compare patterns of fractional anisotropy (FA) and mean diffusivity (MD). ResultsCompared with the NC group, the PiB(+) AD group showed decreased FA in the bilateral frontal, temporal and parietal WM regions and the genu and splenium of the corpus callosum as well as increased MD in the left frontal and temporal WM region. PiB(-) SVaD patients showed decreased FA and increased MD in all WM regions. Direct comparison between PiB(+) AD and PiB(-) SVaD groups showed that the PiB(-) SVaD group had decreased FA across all WM regions and increased MD in all WM regions except occipital regions. Conclusion Our findings suggest that pure AD and pure SVaD have divergent topography of WM microstructural changes including normal appearing WM.en_US
dc.description.sponsorshipThis study was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2065365), by the Korean Healthcare Technology R&D Project Ministry for Health & Welfare Affairs (HI10C2020 and HIC120713), by the Korea Ministry of Environment (MOE) as the Environmental Health Action Program (2014001360002), by the KOSEF NRL program grant (MEST; 2011-0028333), by Samsung Medical Center (CRL-108011&CRS110-14-1) and by the Converging Research Center Program through the Ministry of Science, ICT and Future Planning, Korea (2013K000338).en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectdiffuse tensor imagingen_US
dc.subjectsubcortical vascular dementiaen_US
dc.subjectwhite matter microstructural changesen_US
dc.titleWhite matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementiaen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume22-
dc.identifier.doi10.1111/ene.12645-
dc.relation.page709-716-
dc.relation.journalEUROPEAN JOURNAL OF NEUROLOGY-
dc.contributor.googleauthorKim, Y. J.-
dc.contributor.googleauthorKwon, H. K.-
dc.contributor.googleauthorLee, J. -M.-
dc.contributor.googleauthorKim, Y. J.-
dc.contributor.googleauthorKim, H. J.-
dc.contributor.googleauthorJung, N. -Y.-
dc.contributor.googleauthorKim, S. T.-
dc.contributor.googleauthorLee, K. H.-
dc.contributor.googleauthorNa, D. L.-
dc.contributor.googleauthorSeo, S. W.-
dc.relation.code2015013807-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidljm-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE